RIAM Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. Belongs to the MRL family. Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2|2 A3
Cellular Component:  cell junction; cell projection; cytoplasm; cytoskeleton; cytosol; membrane; plasma membrane; T cell receptor complex
Molecular Function:  protein binding
Biological Process:  positive regulation of cell adhesion; signal transduction; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
Reference #:  Q8R5A3 (UniProtKB)
Alt. Names/Synonyms: 9930118P07Rik; AB1IP; amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein; Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; APBB1-interacting protein 1; Apbb1ip; OTTMUSP00000012300; PREL-1; Prel1; Proline-rich EVH1 ligand 1; Proline-rich protein 48; Prp48; RIAM
Gene Symbols: Apbb1ip
Molecular weight: 74,319 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene