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ANKHD1
May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. Belongs to the mask family. Ubiquitous with high expression in cervix, spleen and brain. Expressed in hematopoietic cells with increased expression in leukemia cells. Isoform 2 is highly expressed in spleen with almost no expression in muscle and brain. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; RNA-binding |
| Chromosomal Location of Human Ortholog: 5q31.3 |
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Cellular Component:
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Molecular Function:
protein binding
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Reference #:
Q8IWZ3
(UniProtKB)
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Alt. Names/Synonyms: ANKH1; ANKHD1; ankyrin repeat and KH domain containing 1; Ankyrin repeat and KH domain-containing protein 1; HIV-1 Vpr-binding ankyrin repeat protein; hMASK; KIAA1085; MASK; MASK1; Multiple ankyrin repeats single KH domain; multiple ankyrin repeats, single KH-domain homolog; PP2500; VBARP; VPR-binding ankyrin repeat protein
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Gene Symbols: ANKHD1
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Molecular weight:
269,458 Da
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Basal Isoelectric point:
5.46
Predict pI for various phosphorylation states
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