PRPS2 Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Belongs to the ribose-phosphate pyrophosphokinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC; Kinase, other; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: X F5|X 78.32 cM
Cellular Component:  cytoplasm; protein-containing complex; ribose phosphate diphosphokinase complex
Molecular Function:  ADP binding; AMP binding; ATP binding; carbohydrate binding; GDP binding; identical protein binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; ribose phosphate diphosphokinase activity; transferase activity
Biological Process:  5-phosphoribose 1-diphosphate biosynthetic process; AMP biosynthetic process; cellular biosynthetic process; nucleoside metabolic process; nucleotide biosynthetic process; phosphorylation; purine nucleotide biosynthetic process; ribonucleoside monophosphate biosynthetic process; ribose phosphate metabolic process
Reference #:  Q9CS42 (UniProtKB)
Alt. Names/Synonyms: 2610101M19Rik; AA589463; AI464149; MGC28388; OTTMUSP00000021121; Phosphoribosyl pyrophosphate synthase II; phosphoribosyl pyrophosphate synthetase 2; phosphoribosyl pyrophosphate synthetase II; Prps-2; Prps2; PRS-II; Ribose-phosphate pyrophosphokinase 2
Gene Symbols: Prps2
Molecular weight: 34,786 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene