PRPS1 Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Belongs to the ribose-phosphate pyrophosphokinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC; Kinase, other; Nucleotide Metabolism - purine
Chromosomal Location of mouse Ortholog: X F1|X 61.35 cM
Cellular Component:  cytoplasm; cytosol; protein-containing complex; ribose phosphate diphosphokinase complex
Molecular Function:  ADP binding; AMP binding; ATP binding; carbohydrate binding; GDP binding; identical protein binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein homodimerization activity; ribose phosphate diphosphokinase activity; transferase activity
Biological Process:  5-phosphoribose 1-diphosphate biosynthetic process; cellular biosynthetic process; hypoxanthine biosynthetic process; nervous system development; nucleotide biosynthetic process; pentose-phosphate shunt; phosphorylation; purine nucleobase metabolic process; purine nucleotide biosynthetic process; ribonucleoside monophosphate biosynthetic process; urate biosynthetic process
Reference #:  Q9D7G0 (UniProtKB)
Alt. Names/Synonyms: 2310010D17Rik; C76571; C76678; OTTMUSP00000020407; Phosphoribosyl pyrophosphate synthase I; phosphoribosyl pyrophosphate synthetase 1; phosphoribosyl pyrophosphate synthetase I; Prps-1; Prps1; PRS-I; Ribose-phosphate pyrophosphokinase 1
Gene Symbols: Prps1
Molecular weight: 34,834 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein