PRPS1 Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Belongs to the ribose-phosphate pyrophosphokinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC; Kinase, other; Nucleotide Metabolism - purine
Chromosomal Location of human Ortholog: Xq22.3
Cellular Component:  cytoplasm; cytosol; ribose phosphate diphosphokinase complex
Molecular Function:  ATP binding; identical protein binding; kinase activity; magnesium ion binding; protein binding; protein homodimerization activity; ribose phosphate diphosphokinase activity
Biological Process:  5-phosphoribose 1-diphosphate biosynthetic process; hypoxanthine biosynthetic process; nervous system development; phosphorylation; purine nucleobase metabolic process; purine nucleotide biosynthetic process; pyrimidine nucleotide biosynthetic process; ribonucleoside monophosphate biosynthetic process; urate biosynthetic process
Disease: Arts Syndrome; Charcot-marie-tooth Disease, X-linked Recessive, 5; Deafness, X-linked 1; Phosphoribosylpyrophosphate Synthetase Superactivity
Reference #:  P60891 (UniProtKB)
Alt. Names/Synonyms: ARTS; CMTX5; deafness 2, perceptive, congenital; deafness, X-linked 2, perceptive, congenital; DFN2; DFNX1; dJ1070B1.2 (phosphoribosyl pyrophosphate synthetase 1); KIAA0967; Phosphoribosyl pyrophosphate synthase I; phosphoribosyl pyrophosphate synthetase 1; PPRibP; PRPS1; PRS-I; PRSI; ribose-phosphate diphosphokinase 1; Ribose-phosphate pyrophosphokinase 1
Gene Symbols: PRPS1
Molecular weight: 34,834 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein