NR2C2 Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior. Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. Belongs to the nuclear hormone receptor family. NR2 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of mouse Ortholog: 6|6 D1
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; metal ion binding; protein binding; protein heterodimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding
Biological Process:  cell differentiation; cerebellum development; meiotic cell cycle; p38MAPK cascade; positive regulation of behavior; positive regulation of embryonic development; positive regulation of myoblast differentiation; positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; spermatogenesis
Reference #:  P49117 (UniProtKB)
Alt. Names/Synonyms: KIAA4145; MGC124356; MGC124357; MGC124358; mKIAA4145; Mtr2r1; Nr2c2; Nuclear receptor subfamily 2 group C member 2; nuclear receptor subfamily 2, group C, member 2; nuclear receptor subfamily 2, group H, member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; orphan receptor, TR4; OTTMUSP00000026154; TAK; Tak1; Testicular receptor 4; Tr4
Gene Symbols: Nr2c2
Molecular weight: 65,239 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA