ATP6V1H Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. Belongs to the V-ATPase H subunit family. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Energy Metabolism - oxidative phosphorylation; Hydrolase
Chromosomal Location of Human Ortholog: 1|1 A1
Cellular Component:  vacuolar proton-transporting V-type ATPase, V1 domain
Molecular Function:  proton-transporting ATPase activity, rotational mechanism
Biological Process:  ATP hydrolysis coupled proton transport; endocytosis; ion transport
Reference #:  Q8BVE3 (UniProtKB)
Alt. Names/Synonyms: 0710001F19Rik; Atp6v1h; ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H; ATPase, H+ transporting, lysosomal V1 subunit H; AU022349; CGI-11; MGC11985; SFD; SFDalpha; SFDbeta; V-ATPase H subunit; V-ATPase subunit H; V-type proton ATPase subunit H; vacuolar ATP synthase subunit H; vacuolar ATPase subunit H; vacuolar proton pump H subunit; Vacuolar proton pump subunit H; VATH; VMA13
Gene Symbols: Atp6v1h
Molecular weight: 55,855 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene