ATP6V1H Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. Belongs to the V-ATPase H subunit family. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Energy Metabolism - oxidative phosphorylation; Hydrolase
Chromosomal Location of human Ortholog: 8q11.23
Cellular Component:  cytosol; plasma membrane; vacuolar proton-transporting V-type ATPase, V1 domain
Molecular Function:  enzyme regulator activity; protein binding; proton-transporting ATPase activity, rotational mechanism
Biological Process:  ATP hydrolysis coupled proton transport; endocytosis; insulin receptor signaling pathway; ion transmembrane transport; phagosome acidification; regulation of catalytic activity; regulation of defense response to virus by virus; regulation of macroautophagy; transferrin transport; vacuolar acidification
Reference #:  Q9UI12 (UniProtKB)
Alt. Names/Synonyms: ATP6V1H; ATPase H+ transporting V1 subunit H; ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H; CGI-11; MSTP042; NBP1; Nef-binding protein 1; Protein VMA13 homolog; SFD; SFDalpha; SFDbeta; V-ATPase 50/57 kDa subunits; V-ATPase H subunit; V-ATPase subunit H; V-type proton ATPase subunit H; vacuolar ATP synthase subunit H; vacuolar ATPase subunit H; vacuolar proton pump H subunit; Vacuolar proton pump subunit H; Vacuolar proton pump subunit SFD; VATH; VMA13
Gene Symbols: ATP6V1H
Molecular weight: 55,883 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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