UBE2A Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Belongs to the ubiquitin-conjugating enzyme family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: Xq24
Cellular Component:  chromatin; cytosol; HULC complex; nucleoplasm; XY body
Molecular Function:  ATP binding; protein binding; ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity
Biological Process:  blastocyst hatching; DNA repair; histone H2A ubiquitination; maternal process involved in female pregnancy; positive regulation of cell proliferation; postreplication repair; protein autoubiquitination; protein K11-linked ubiquitination; protein K48-linked ubiquitination; protein polyubiquitination; protein ubiquitination; response to UV; ubiquitin-dependent protein catabolic process
Disease: Mental Retardation, X-linked, Syndromic, Nascimento Type
Reference #:  P49459 (UniProtKB)
Alt. Names/Synonyms: hHR6A; HR6A; RAD6 homolog A; RAD6A; UBC2; UBE2A; Ubiquitin carrier protein A; Ubiquitin-conjugating enzyme E2 A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); Ubiquitin-protein ligase A
Gene Symbols: UBE2A
Molecular weight: 17,315 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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UBE2A

Protein Structure Not Found.


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