MIB1 E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 18q11.2
Cellular Component:  centrosome; cytoplasm; cytoplasmic vesicle; cytosol; plasma membrane
Molecular Function:  protein binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding
Biological Process:  blood vessel development; endocytosis; heart looping; in utero embryonic development; negative regulation of neuron differentiation; neural tube formation; neuron differentiation; Notch signaling pathway; positive regulation of endocytosis; protein ubiquitination; somitogenesis; ubiquitin-dependent protein catabolic process
Disease: Left Ventricular Noncompaction 7
Reference #:  Q86YT6 (UniProtKB)
Alt. Names/Synonyms: DAPK-interacting protein 1; DIP-1; DIP1; DKFZp686I0769; DKFZp761M1710; E3 ubiquitin-protein ligase MIB1; FLJ90676; KIAA1323; LVNC7; MGC129659; MGC129660; MIB; MIB1; Mind bomb homolog 1; mindbomb E3 ubiquitin protein ligase 1; mindbomb homolog 1 (Drosophila); RING-type E3 ubiquitin transferase MIB1; ubiquitin ligase mind bomb; ubiquitin ligase protein MIB1; Zinc finger ZZ type with ankyrin repeat domain protein 2; ZZANK2; ZZZ6
Gene Symbols: MIB1
Molecular weight: 110,136 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein