RALY RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis. May be a heterogeneous nuclear ribonucleoprotein (hnRNP). Belongs to the RRM HNRPC family. RALY subfamily. Expressed in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Weakly expressed in placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 2 H1|2 76.83 cM
Cellular Component:  catalytic step 2 spliceosome; nucleus; spliceosomal complex
Molecular Function:  nucleic acid binding; RNA binding; transcription coregulator activity
Biological Process:  cholesterol homeostasis; mRNA processing; regulation of nucleic acid-templated transcription; RNA splicing
Reference #:  Q64012 (UniProtKB)
Alt. Names/Synonyms: AI663842; hnRNP associated with lethal yellow protein; hnRNP-associated with lethal yellow; Maternally-expressed hnRNP C-related protein; Merc; OTTMUSP00000017055; OTTMUSP00000017056; Raly; RNA-binding protein Raly
Gene Symbols: Raly
Molecular weight: 33,188 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
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RALY

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene