RALY RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis. May be a heterogeneous nuclear ribonucleoprotein (hnRNP). Belongs to the RRM HNRPC family. RALY subfamily. Expressed in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Weakly expressed in placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of human Ortholog: 20q11.22
Cellular Component:  catalytic step 2 spliceosome; nucleus
Molecular Function:  protein binding; RNA binding; transcription coregulator activity
Biological Process:  cholesterol homeostasis; DNA-templated transcription; mRNA splicing, via spliceosome; negative regulation of transcription by RNA polymerase II
Reference #:  Q9UKM9 (UniProtKB)
Alt. Names/Synonyms: Autoantigen p542; Heterogeneous nuclear ribonucleoprotein C-like 2; hnRNP associated with lethal yellow protein homolog; hnRNP core protein C-like 2; HNRPCL2; MGC117312; P542; RALY; RALY heterogeneous nuclear ribonucleoprotein; RNA binding protein (autoantigenic, hnRNP-associated with lethal yellow); RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse)); RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog); RNA-binding protein (autoantigenic); RNA-binding protein (autoantigenic, hnRNP-associated with lethal yellow); RNA-binding protein Raly
Gene Symbols: RALY
Molecular weight: 32,463 Da
Basal Isoelectric point: 9.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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RALY

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein