RALY
RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis. May be a heterogeneous nuclear ribonucleoprotein (hnRNP). Belongs to the RRM HNRPC family. RALY subfamily. Expressed in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Weakly expressed in placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: RNA splicing; RNA-binding; Spliceosome |
Chromosomal Location of human Ortholog: 20q11.22 |
Cellular Component:
catalytic step 2 spliceosome; nucleus
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Molecular Function:
protein binding; RNA binding; transcription coregulator activity
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Biological Process:
cholesterol homeostasis; DNA-templated transcription; mRNA splicing, via spliceosome; negative regulation of transcription by RNA polymerase II
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Reference #:
Q9UKM9
(UniProtKB)
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Alt. Names/Synonyms: Autoantigen p542; Heterogeneous nuclear ribonucleoprotein C-like 2; hnRNP associated with lethal yellow protein homolog; hnRNP core protein C-like 2; HNRPCL2; MGC117312; P542; RALY; RALY heterogeneous nuclear ribonucleoprotein; RNA binding protein (autoantigenic, hnRNP-associated with lethal yellow); RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse)); RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog); RNA-binding protein (autoantigenic); RNA-binding protein (autoantigenic, hnRNP-associated with lethal yellow); RNA-binding protein Raly
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Gene Symbols: RALY
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Molecular weight:
32,463 Da
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Basal Isoelectric point:
9.2
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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