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KIF20A
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Microtubule-binding; Motor |
| Chromosomal Location of mouse Ortholog: 18 B1|18 18.69 cM |
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Cellular Component:
cytoplasm; cytoskeleton; Golgi apparatus; intercellular bridge; kinesin complex; microtubule; midbody; nucleoplasm; nucleus; spindle
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Molecular Function:
ATP binding; ATP hydrolysis activity; microtubule binding; microtubule motor activity; nucleotide binding; protein kinase binding
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Biological Process:
microtubule bundle formation; microtubule-based movement; midbody abscission; mitotic cytokinesis; protein transport; regulation of cytokinesis
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Reference #:
P97329
(UniProtKB)
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Alt. Names/Synonyms: AA415432; KI20A; Kif20a; kinesin family member 20A; Kinesin-like protein 174; Kinesin-like protein KIF20A; Rab6; Rab6, kinesin-like; Rab6-interacting kinesin-like protein; Rab6kifl; Rabkinesin-6
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Gene Symbols: Kif20a
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Molecular weight:
99,876 Da
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Basal Isoelectric point:
6.55
Predict pI for various phosphorylation states
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