PSMD3 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Belongs to the proteasome subunit S3 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 11 D|11 62.39 cM
Cellular Component:  proteasome accessory complex; proteasome complex; proteasome regulatory particle; proteasome regulatory particle, lid subcomplex
Molecular Function:  enzyme regulator activity; protein binding
Biological Process:  regulation of protein catabolic process; ubiquitin-dependent protein catabolic process
Reference #:  P14685 (UniProtKB)
Alt. Names/Synonyms: 26S proteasome non-ATPase regulatory subunit 3; 26S proteasome regulatory subunit RPN3; 26S proteasome regulatory subunit S3; AI255837; Ant; AntP91a; D11Bwg1349e; OTTMUSP00000006778; P91a; proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; Proteasome subunit p58; Psd3; Psmd3; tissue specific transplantation antigen P91A; Transplantation antigen P91A; Tsta; Tstap91a; Tum-P91A antigen
Gene Symbols: Psmd3
Molecular weight: 60,718 Da
Basal Isoelectric point: 8.48  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene