PSMD3 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Belongs to the proteasome subunit S3 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 17q21.1
Cellular Component:  cytosol; extracellular region; ficolin-1-rich granule lumen; nucleoplasm; proteasome accessory complex; proteasome complex; secretory granule lumen
Molecular Function:  enzyme regulator activity; protein binding
Biological Process:  anaphase-promoting complex-dependent catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; Fc-epsilon receptor signaling pathway; interleukin-1-mediated signaling pathway; MAPK cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of G2/M transition of mitotic cell cycle; neutrophil degranulation; NIK/NF-kappaB signaling; positive regulation of canonical Wnt signaling pathway; post-translational protein modification; proteasome-mediated ubiquitin-dependent protein catabolic process; protein deubiquitination; protein polyubiquitination; regulation of catalytic activity; regulation of cellular amino acid metabolic process; regulation of hematopoietic stem cell differentiation; regulation of mitotic cell cycle phase transition; regulation of mRNA stability; regulation of protein catabolic process; regulation of transcription from RNA polymerase II promoter in response to hypoxia; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; transmembrane transport; tumor necrosis factor-mediated signaling pathway; Wnt signaling pathway, planar cell polarity pathway
Reference #:  O43242 (UniProtKB)
Alt. Names/Synonyms: 26S proteasome non-ATPase regulatory subunit 3; 26S proteasome regulatory subunit S3; P58; proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; proteasome 26S non-ATPase subunit 3; Proteasome subunit p58; PSMD3; RPN3; S3
Gene Symbols: PSMD3
Molecular weight: 60,978 Da
Basal Isoelectric point: 8.47  Predict pI for various phosphorylation states
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PSMD3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene