PELO Required for normal chromosome segregation during cell division and genomic stability. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). Belongs to the eukaryotic release factor 1 family. Pelota subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.-.-; Hydrolase
Chromosomal Location of Human Ortholog: 13|13 D2.2
Cellular Component:  cytoplasm; nucleus
Molecular Function:  endonuclease activity; hydrolase activity; metal ion binding; nuclease activity; protein binding; ribosome binding
Biological Process:  cell cycle; cell division; chromosome organization; endoderm development; inner cell mass cell proliferation; mesenchymal to epithelial transition; nonfunctional rRNA decay; nuclear-transcribed mRNA catabolic process, no-go decay; nuclear-transcribed mRNA catabolic process, non-stop decay; positive regulation of BMP signaling pathway; ribosome disassembly; RNA surveillance; stem cell population maintenance
Reference #:  Q80X73 (UniProtKB)
Alt. Names/Synonyms: AA409897; AI852218; Pelo; pelota homolog (Drosophila); Protein pelota homolog
Gene Symbols: Pelo
Molecular weight: 43,349 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene