eIF2B-alpha Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Belongs to the eIF-2B alpha/beta/delta subunits family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component:  cytoplasm; cytosol; eukaryotic translation initiation factor 2B complex; membrane; plasma membrane
Molecular Function:  identical protein binding; protein binding
Biological Process:  oligodendrocyte development; response to glucose; response to heat; response to peptide hormone; T cell receptor signaling pathway; translational initiation
Disease: Leukoencephalopathy With Vanishing White Matter
Reference #:  Q14232 (UniProtKB)
Alt. Names/Synonyms: EI2BA; eIF-2B GDP-GTP exchange factor subunit alpha; EIF2B; EIF2B1; EIF2BA; eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa; MGC117409; MGC125868; MGC125869; Translation initiation factor eIF-2B subunit alpha
Gene Symbols: EIF2B1
Molecular weight: 33,712 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2  |  Translational Control
Select Structure to View Below

eIF2B-alpha

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene