|
PPIE
Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity. Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. Found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cyclophilin; EC 5.2.1.8; Isomerase; RNA splicing; Spliceosome |
| Chromosomal Location of Human Ortholog: 4|4 D2.2 |
|
Cellular Component:
catalytic step 2 spliceosome; cytosol; nuclear speck; nucleus; spliceosomal complex; U2-type catalytic step 2 spliceosome
|
|
Molecular Function:
cyclosporin A binding; isomerase activity; mRNA binding; nucleic acid binding; peptidyl-prolyl cis-trans isomerase activity; poly(A) binding; RNA binding; unfolded protein binding
|
|
Biological Process:
mRNA processing; mRNA splicing, via spliceosome; positive regulation of viral genome replication; protein folding; protein peptidyl-prolyl isomerization; protein refolding; regulation of transcription, DNA-templated; RNA splicing
|
|
Reference #:
Q9QZH3
(UniProtKB)
|
|
Alt. Names/Synonyms: 2010010D16Rik; Cyclophilin E; Cyclophilin-33; Cyp33; OTTMUSP00000009312; Peptidyl-prolyl cis-trans isomerase E; peptidylprolyl isomerase E (cyclophilin E); PPIase E; Ppie; Rotamase E
|
|
Gene Symbols: Ppie
|
|
Molecular weight:
33,449 Da
|
|
Basal Isoelectric point:
5.41
Predict pI for various phosphorylation states
|
