PPIE Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity. Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. Found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cyclophilin; EC; Isomerase; RNA splicing; Spliceosome
Chromosomal Location of human Ortholog: 1p34.2
Cellular Component:  catalytic step 2 spliceosome; cytosol; extracellular region; ficolin-1-rich granule lumen; nuclear speck; nucleoplasm; nucleus; secretory granule lumen; U2-type catalytic step 2 spliceosome
Molecular Function:  cyclosporin A binding; mRNA binding; peptidyl-prolyl cis-trans isomerase activity; poly(A) binding; protein binding; RNA binding
Biological Process:  mRNA splicing, via spliceosome; neutrophil degranulation; positive regulation of viral genome replication; protein peptidyl-prolyl isomerization; regulation of transcription, DNA-templated; transcription-coupled nucleotide-excision repair
Reference #:  Q9UNP9 (UniProtKB)
Alt. Names/Synonyms: cyclophilin 33; Cyclophilin E; Cyclophilin-33; CYP-33; CYP33; MGC111222; MGC3736; Peptidyl-prolyl cis-trans isomerase E; peptidylprolyl isomerase E; peptidylprolyl isomerase E (cyclophilin E); peptidylprolyl isomerase E, isoform 1; PPIase E; PPIE; Rotamase E
Gene Symbols: PPIE
Molecular weight: 33,431 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein