DPM1 Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. Belongs to the glycosyltransferase 2 family. Note: This description may include information from UniProtKB.
Protein type: EC 2.4.1.83; Glycan Metabolism - N-glycan biosynthesis; Transferase
Chromosomal Location of mouse Ortholog: 2|2 H3
Cellular Component:  dolichol-phosphate-mannose synthase complex; endoplasmic reticulum; endoplasmic reticulum membrane; membrane
Molecular Function:  alcohol binding; dolichyl-phosphate beta-D-mannosyltransferase activity; dolichyl-phosphate-mannose-protein mannosyltransferase activity; mannose binding
Biological Process:  dolichol metabolic process; dolichol-linked oligosaccharide biosynthetic process; GDP-mannose metabolic process; GPI anchor biosynthetic process; protein mannosylation; protein O-linked mannosylation
Reference #:  O70152 (UniProtKB)
Alt. Names/Synonyms: AI118379; AI194292; dolichol-phosphate (beta-D) mannosyltransferase 1; Dolichol-phosphate mannose synthase; Dolichol-phosphate mannose synthase subunit 1; Dolichol-phosphate mannosyltransferase; Dolichol-phosphate mannosyltransferase subunit 1; Dolichyl-phosphate beta-D-mannosyltransferase; Dolichyl-phosphate beta-D-mannosyltransferase subunit 1; DPM synthase; DPM synthase subunit 1; Dpm1; Mannose-P-dolichol synthase; Mannose-P-dolichol synthase subunit 1; MPD synthase; OTTMUSP00000017164
Gene Symbols: Dpm1
Molecular weight: 29,175 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
Select Structure to View Below

DPM1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein