CTBP2 Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation. Isoform 2 probably acts as a scaffold for specialized synapses. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of mouse Ortholog: 7 F3|7 76.32 cM
Cellular Component:  cytosol; GABA-ergic synapse; glutamatergic synapse; nucleus; photoreceptor ribbon synapse; presynaptic active zone cytoplasmic component; presynaptic cytosol; ribbon synapse; synapse; transcription repressor complex
Molecular Function:  chromatin binding; DNA-binding transcription factor binding; identical protein binding; NAD binding; nuclear retinoic acid receptor binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein binding; protein kinase binding; protein-containing complex binding; structural constituent of presynaptic active zone; transcription coactivator activity; transcription coregulator binding; transcription corepressor activity; transcription corepressor binding
Biological Process:  cell differentiation; cellular response to leukemia inhibitory factor; negative regulation of DNA-templated transcription; positive regulation of chromatin binding; positive regulation of retinoic acid receptor signaling pathway; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; synaptic vesicle docking; white fat cell differentiation
Reference #:  P56546 (UniProtKB)
Alt. Names/Synonyms: AA407280; C-terminal binding protein 2; C-terminal-binding protein 2; CtBP2; D7Ertd45; D7Ertd45e; gene trap ROSA b-geo 6; Gtrge; Gtrgeo6; Ribe; Ribeye
Gene Symbols: Ctbp2
Molecular weight: 48,957 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA