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LARS
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. Belongs to the class-I aminoacyl-tRNA synthetase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Aminoacyl-tRNA synthetase; EC 6.1.1.4; Ligase; Translation; Translation regulation |
| Chromosomal Location of mouse Ortholog: 18|18 B3 |
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Cellular Component:
aminoacyl-tRNA synthetase multienzyme complex; cytoplasm; cytosol; endomembrane system; endoplasmic reticulum; lysosome; nuclear body
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Molecular Function:
aminoacyl-tRNA editing activity; aminoacyl-tRNA ligase activity; ATP binding; glutamine-tRNA ligase activity; GTPase activator activity; leucine-tRNA ligase activity; ligase activity; nucleotide binding
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Biological Process:
cellular response to amino acid starvation; cellular response to amino acid stimulus; cellular response to leucine; cellular response to leucine starvation; glutaminyl-tRNA aminoacylation; leucyl-tRNA aminoacylation; positive regulation of GTPase activity; positive regulation of TOR signaling; positive regulation of TORC1 signaling; regulation of cell size; translation; tRNA aminoacylation for protein translation
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Reference #:
Q8BMJ2
(UniProtKB)
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Alt. Names/Synonyms: 2310045K21Rik; 3110009L02Rik; AW536573; Lars; Lars1; Leucine--tRNA ligase; Leucine--tRNA ligase, cytoplasmic; leucyl-tRNA synthetase; Leucyl-tRNA synthetase, cytoplasmic; LeuRS; mKIAA1352; SYLC
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Gene Symbols: Lars1
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Molecular weight:
134,192 Da
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Basal Isoelectric point:
6.64
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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