LARS Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. Belongs to the class-I aminoacyl-tRNA synthetase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Aminoacyl-tRNA synthetase; EC; Ligase; Translation; Translation regulation
Chromosomal Location of Human Ortholog: 18|18 B3
Cellular Component:  aminoacyl-tRNA synthetase multienzyme complex; cytoplasm; cytosol; endomembrane system; endoplasmic reticulum; lysosome; nuclear body
Molecular Function:  aminoacyl-tRNA editing activity; aminoacyl-tRNA ligase activity; ATP binding; glutamine-tRNA ligase activity; GTPase activator activity; leucine-tRNA ligase activity; ligase activity; nucleotide binding
Biological Process:  cellular response to amino acid starvation; cellular response to amino acid stimulus; cellular response to leucine; cellular response to leucine starvation; glutaminyl-tRNA aminoacylation; leucyl-tRNA aminoacylation; negative regulation of autophagy; positive regulation of GTPase activity; positive regulation of TORC1 signaling; protein targeting to lysosome; regulation of cell size; translation; tRNA aminoacylation for protein translation
Reference #:  Q8BMJ2 (UniProtKB)
Alt. Names/Synonyms: 2310045K21Rik; 3110009L02Rik; AW536573; Lars; Leucine--tRNA ligase; Leucine--tRNA ligase, cytoplasmic; leucyl-tRNA synthetase; Leucyl-tRNA synthetase, cytoplasmic; LeuRS; mKIAA1352; SYLC
Gene Symbols: Lars
Molecular weight: 134,192 Da
Basal Isoelectric point: 6.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene