LARS Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. Belongs to the class-I aminoacyl-tRNA synthetase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Aminoacyl-tRNA synthetase; EC; Ligase; Translation; Translation regulation
Chromosomal Location of Human Ortholog: 5q32
Cellular Component:  aminoacyl-tRNA synthetase multienzyme complex; cytoplasm; cytosol; endomembrane system; endoplasmic reticulum; lysosome; nuclear body
Molecular Function:  aminoacyl-tRNA editing activity; ATP binding; glutamine-tRNA ligase activity; GTPase activator activity; leucine-tRNA ligase activity; protein binding
Biological Process:  aminoacyl-tRNA metabolism involved in translational fidelity; cellular response to amino acid starvation; cellular response to amino acid stimulus; cellular response to leucine; cellular response to leucine starvation; glutaminyl-tRNA aminoacylation; negative regulation of autophagy; positive regulation of GTPase activity; positive regulation of TORC1 signaling; protein targeting to lysosome; regulation of cell size; tRNA aminoacylation for protein translation
Disease: Infantile Liver Failure Syndrome 1
Reference #:  Q9P2J5 (UniProtKB)
Alt. Names/Synonyms: cytoplasmic leucyl-tRNA synthetase; cytosolic leucyl-tRNA synthetase; FLJ10595; FLJ21788; hr025Cl; HSPC192; ILFS1; KIAA1352; LARS; LARS1; leucine translase; leucine tRNA ligase 1, cytoplasmic; Leucine--tRNA ligase; Leucine--tRNA ligase, cytoplasmic; leucine-tRNA ligase; leucyl-tRNA synthetase; leucyl-tRNA synthetase 1; Leucyl-tRNA synthetase, cytoplasmic; LeuRS; LEUS; LFIS; LRS; PIG44; proliferation-inducing gene 44; RNTLS; SYLC
Gene Symbols: LARS
Molecular weight: 134,466 Da
Basal Isoelectric point: 6.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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