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GTF2E1
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. Belongs to the TFIIE alpha subunit family. Note: This description may include information from UniProtKB.
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| Protein type: Transcription initiation complex |
| Chromosomal Location of mouse Ortholog: 16|16 B3 |
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Cellular Component:
cytosol; nucleoplasm; nucleus; transcription factor TFIID complex; transcription factor TFIIE complex; transcription preinitiation complex
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Molecular Function:
metal ion binding; molecular adaptor activity; RNA polymerase II general transcription initiation factor activity
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Biological Process:
transcription by RNA polymerase II; transcription initiation at RNA polymerase II promoter; transcription open complex formation at RNA polymerase II promoter
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Reference #:
Q9D0D5
(UniProtKB)
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Alt. Names/Synonyms: 2610024P03Rik; 56kD; 56kDa; AI303800; FE; general transcription factor II E, polypeptide 1 (alpha subunit); general transcription factor II E, polypeptide 1 (alpha subunit, 56kDa); General transcription factor IIE 56 kDa subunit; General transcription factor IIE subunit 1; general transcription factor IIE, polypeptide 1 (alpha subunit, 56kDa); Gtf2e1; OTTMUSP00000030935; T2EA; TFII; TFIIE-A; TFIIE-alpha; Transcription initiation factor IIE subunit alpha
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Gene Symbols: Gtf2e1
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Molecular weight:
49,593 Da
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Basal Isoelectric point:
4.77
Predict pI for various phosphorylation states
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CST Pathways:
Protein Acetylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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