GTF2E1 Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. Belongs to the TFIIE alpha subunit family. Note: This description may include information from UniProtKB.
Protein type: Transcription initiation complex
Chromosomal Location of mouse Ortholog: 16|16 B3
Cellular Component:  cytosol; nucleoplasm; nucleus; transcription factor TFIID complex; transcription factor TFIIE complex; transcription preinitiation complex
Molecular Function:  metal ion binding; molecular adaptor activity; RNA polymerase II general transcription initiation factor activity
Biological Process:  transcription by RNA polymerase II; transcription initiation at RNA polymerase II promoter; transcription open complex formation at RNA polymerase II promoter
Reference #:  Q9D0D5 (UniProtKB)
Alt. Names/Synonyms: 2610024P03Rik; 56kD; 56kDa; AI303800; FE; general transcription factor II E, polypeptide 1 (alpha subunit); general transcription factor II E, polypeptide 1 (alpha subunit, 56kDa); General transcription factor IIE 56 kDa subunit; General transcription factor IIE subunit 1; general transcription factor IIE, polypeptide 1 (alpha subunit, 56kDa); Gtf2e1; OTTMUSP00000030935; T2EA; TFII; TFIIE-A; TFIIE-alpha; Transcription initiation factor IIE subunit alpha
Gene Symbols: Gtf2e1
Molecular weight: 49,593 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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GTF2E1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene