GTF2E1 Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. Belongs to the TFIIE alpha subunit family. Note: This description may include information from UniProtKB.
Protein type: Transcription initiation complex
Chromosomal Location of Human Ortholog: 3q13.33
Cellular Component:  cytosol; nucleoplasm; nucleus; transcription factor TFIID complex; transcriptional preinitiation complex
Molecular Function:  metal ion binding; protein binding; RNA polymerase II general transcription initiation factor activity; sequence-specific DNA binding
Biological Process:  snRNA transcription by RNA polymerase II; transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter; viral process
Reference #:  P29083 (UniProtKB)
Alt. Names/Synonyms: FE; General transcription factor IIE 56 kDa subunit; General transcription factor IIE subunit 1; general transcription factor IIE, polypeptide 1, alpha 56kDa; GTF2E1; T2EA; TF2E1; TFIIE-A; TFIIE-alpha; Transcription initiation factor IIE subunit alpha
Gene Symbols: GTF2E1
Molecular weight: 49,452 Da
Basal Isoelectric point: 4.74  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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