RUVBL2 a transcriptional-regulatory protein with ATP-dependent DNA helicase (3' to 5') activity that is stimulated by single-stranded DNA. Hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2. Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes. Belongs to the RuvB family. Ubiquitously expressed. Highly expressed in testis and thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase
Chromosomal Location of human Ortholog: 19q13.33
Cellular Component:  centrosome; chaperone complex; cytoplasm; cytosol; dynein axonemal particle; euchromatin; Ino80 complex; membrane; MLL1 complex; NuA4 histone acetyltransferase complex; nuclear matrix; nucleoplasm; nucleosome; nucleus; R2TP complex; ribonucleoprotein complex; RPAP3/R2TP/prefoldin-like complex; Swr1 complex
Molecular Function:  ADP binding; ATP binding; ATP hydrolysis activity; ATPase binding; beta-catenin binding; chromatin DNA binding; DNA helicase activity; identical protein binding; promoter-enhancer loop anchoring activity; protein binding; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; TBP-class protein binding; TFIID-class transcription factor complex binding; transcription corepressor activity; unfolded protein binding
Biological Process:  box C/D snoRNP assembly; cellular response to estradiol stimulus; cellular response to UV; chromatin remodeling; DNA duplex unwinding; DNA recombination; DNA repair; establishment of protein localization to chromatin; histone acetylation; histone H2A acetylation; histone H4 acetylation; negative regulation of canonical Wnt signaling pathway; negative regulation of DNA-templated transcription; positive regulation of DNA repair; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair via homologous recombination; positive regulation of histone acetylation; positive regulation of telomere maintenance in response to DNA damage; positive regulation of transcription by RNA polymerase II; protein folding; protein stabilization; regulation of apoptotic process; regulation of cell cycle; regulation of chromosome organization; regulation of DNA repair; regulation of DNA replication; regulation of DNA strand elongation; regulation of DNA-templated transcription; regulation of double-strand break repair; regulation of embryonic development; regulation of transcription by RNA polymerase II; telomere maintenance
Reference #:  Q9Y230 (UniProtKB)
Alt. Names/Synonyms: 48 kDa TATA box-binding protein-interacting protein; 48 kDa TBP-interacting protein; 51 kDa erythrocyte cytosolic protein; CGI-46; ECP-51; ECP51; erythrocyte cytosolic protein, 51-KD; INO80 complex subunit J; INO80J; Repressing pontin 52; REPTIN; Reptin 52; Reptin52; reptin52 protein; RuvB (E coli homolog)-like 2; RuvB like AAA ATPase 2; RuvB-like 2; RuvB-like 2 (E. coli); RUVB2; RUVBL2; RVB2; TAP54-beta; TBP-interacting protein, 48-KD; TIH2; TIP48; TIP49B; TIP60-associated protein 54-beta
Gene Symbols: RUVBL2
Molecular weight: 51,157 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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