PKAR1B Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Belongs to the cAMP-dependent kinase regulatory chain family. Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 7p22.3
Cellular Component:  cAMP-dependent protein kinase complex; ciliary base; cytosol; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; plasma membrane; Schaffer collateral - CA1 synapse
Molecular Function:  cAMP binding; cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; protein binding; protein kinase A catalytic subunit binding
Biological Process:  activation of protein kinase A activity; blood coagulation; cellular response to glucagon stimulus; learning or memory; modulation of chemical synaptic transmission; negative regulation of cAMP-dependent protein kinase activity; protein phosphorylation; regulation of synaptic vesicle cycle; renal water homeostasis
Reference #:  P31321 (UniProtKB)
Alt. Names/Synonyms: cAMP-dependent protein kinase type I-beta regulatory subunit; KAP1; PKAR1B; PRKAR1; PRKAR1B; protein kinase cAMP-dependent type I regulatory subunit beta; protein kinase, cAMP-dependent, regulatory subunit type I beta; protein kinase, cAMP-dependent, regulatory, type I, beta
Gene Symbols: PRKAR1B
Molecular weight: 43,073 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Parkinson's Disease
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PKAR1B

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein