eIF2-gamma As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B. Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. Expressed in testis, brain, liver and muscle. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: Xp22.11
Cellular Component:  cytoplasm; cytosol; eukaryotic translation initiation factor 2 complex
Molecular Function:  GTP binding; GTPase activity; protein binding; translation factor activity, RNA binding; translation initiation factor activity
Biological Process:  translational initiation; transmembrane transport
Disease: Mehmo Syndrome
Reference #:  P41091 (UniProtKB)
Alt. Names/Synonyms: eIF-2-gamma X; eIF-2gA; eIF-2gX; EIF2; EIF2G; EIF2gamma; EIF2S3; Eukaryotic translation initiation factor 2 subunit 3; Eukaryotic translation initiation factor 2 subunit gamma X; eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa; eukaryotic translation initiation factor 2G; IF2G
Gene Symbols: EIF2S3
Molecular weight: 51,109 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2  |  Translational Control
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Protein Structure Not Found.

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