MED17 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 17 family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q21
Cellular Component:  mediator complex; nucleoplasm; nucleus; transcription factor complex; ubiquitin ligase complex
Molecular Function:  nuclear receptor transcription coactivator activity; protein binding; thyroid hormone receptor binding; transcription coactivator activity; transcription coregulator activity; ubiquitin protein ligase activity; vitamin D receptor binding
Biological Process:  positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein ubiquitination; regulation of transcription by RNA polymerase II; stem cell population maintenance; transcription initiation from RNA polymerase II promoter
Disease: Microcephaly, Postnatal Progressive, With Seizures And Brain Atrophy
Reference #:  Q9NVC6 (UniProtKB)
Alt. Names/Synonyms: Activator-recruited cofactor 77 kDa component; ARC77; Cofactor required for Sp1 transcriptional activation subunit 6; cofactor required for Sp1 transcriptional activation, subunit 6 (77kD); cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa; CRSP complex subunit 6; CRSP6; CRSP77; DRIP77; DRIP80; epididymis secretory sperm binding protein; FLJ10812; MED17; Mediator complex subunit 17; Mediator of RNA polymerase II transcription subunit 17; SRB4; Thyroid hormone receptor-associated protein complex 80 kDa component; thyroid hormone receptor-associated protein, 80-KD subunit; Transcriptional coactivator CRSP77; TRAP80; vitamin D receptor interacting protein 80-kD; Vitamin D3 receptor-interacting protein complex 80 kDa component
Gene Symbols: MED17
Molecular weight: 72,890 Da
Basal Isoelectric point: 7.05  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA