IFIT5 Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments. Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and selectively binds AT-rich dsDNA. Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7. Belongs to the IFIT family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of human Ortholog: 10q23.31
Cellular Component:  actin cytoskeleton; apical part of cell; cytosol; plasma membrane; ruffle membrane
Molecular Function:  double-stranded DNA binding; poly(U) RNA binding; protein binding; RNA binding; RNA cap binding; single-stranded RNA binding; tRNA binding
Biological Process:  defense response to virus; innate immune response; negative regulation of viral genome replication; positive regulation of I-kappaB kinase/NF-kappaB signaling
Reference #:  Q13325 (UniProtKB)
Alt. Names/Synonyms: FLJ53857; FLJ92678; IFIT-5; IFIT5; interferon induced protein with tetratricopeptide repeats 5; Interferon-induced 58 kDa protein; Interferon-induced protein with tetratricopeptide repeats 5; ISG58; P58; Retinoic acid- and interferon-inducible 58 kDa protein; retinoic acid- and interferon-inducible protein (58kD); RI58
Gene Symbols: IFIT5
Molecular weight: 55,847 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein