UXT Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region. Belongs to the UXT family. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: X|X A1.3
Cellular Component:  centrosome; chromatin; cytoplasm; cytoskeleton; gamma-tubulin complex; nucleus
Molecular Function:  beta-tubulin binding; chromatin binding; transcription corepressor activity
Biological Process:  apoptosis; centrosome cycle; microtubule cytoskeleton organization; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; transcription, DNA-dependent
Reference #:  Q9WTZ0 (UniProtKB)
Alt. Names/Synonyms: 0910002B17Rik; OTTMUSP00000018690; Protein UXT; ubiquitously expressed transcript; Ubiquitously expressed transcript protein; Uxt
Gene Symbols: Uxt
Molecular weight: 18,187 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
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UXT

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein