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UXT
Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Isoform 1: Plays a role in protecting cells against TNF-alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP. Belongs to the UXT family. Ubiquitous (PubMed:10087202, PubMed:11854421, PubMed:17635584, PubMed:11827465). Expressed in prostate epithelial cells (PubMed:21730289). Expressed in mammary epithelial cells (PubMed:28106301). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus (PubMed:11854421, PubMed:17635584, PubMed:11827465). Overexpressed in a number of tumor tissues (PubMed:11854421, PubMed:16221885, PubMed:28106301). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: Xp11.23 |
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Cellular Component:
centrosome; cytoplasm; cytoskeleton; nucleoplasm; nucleus; protein folding chaperone complex; RPAP3/R2TP/prefoldin-like complex; spindle pole
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Molecular Function:
actin filament binding; beta-tubulin binding; chromatin binding; microtubule binding; protein binding; transcription corepressor activity
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Biological Process:
apoptotic process; centrosome cycle; microtubule cytoskeleton organization; mitochondrion transport along microtubule; negative regulation of transcription by RNA polymerase II; protein stabilization
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Reference #:
Q9UBK9
(UniProtKB)
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Alt. Names/Synonyms: Androgen receptor trapped clone 27 protein; ART-27; Protein UXT; SKP2-associated alpha PFD 1; STAP1; ubiquitously expressed prefoldin like chaperone; Ubiquitously expressed transcript protein; ubiquitously-expressed transcript; UXT
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Gene Symbols: UXT
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Molecular weight:
18,246 Da
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Basal Isoelectric point:
7.02
Predict pI for various phosphorylation states
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| Select Structure to View Below |
UXT
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