EFT5 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. Expressed in all tissues, with the highest levels of expression in skeletal muscle, liver and kidney. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation elongation
Chromosomal Location of Human Ortholog: 12q14.1
Cellular Component:  mitochondrion; nucleus
Molecular Function:  protein binding
Biological Process:  regulation of DNA-templated transcription, elongation; regulation of mitochondrial translation; translational elongation
Disease: Combined Oxidative Phosphorylation Deficiency 3
Reference #:  P43897 (UniProtKB)
Alt. Names/Synonyms: EF-Ts; EF-TsMt; EFT5; EFTS; EFTSMT; Elongation factor Ts, mitochondrial; mitochondrial elongation factor Ts; Ts translation elongation factor, mitochondrial; TSFM
Gene Symbols: TSFM
Molecular weight: 35,391 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
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EFT5

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein