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EFT5
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. Expressed in all tissues, with the highest levels of expression in skeletal muscle, liver and kidney. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Translation; Translation elongation |
| Chromosomal Location of Human Ortholog: 12q14.1 |
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Cellular Component:
mitochondrion; nucleus
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Molecular Function:
protein binding
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Biological Process:
regulation of DNA-templated transcription, elongation; regulation of mitochondrial translation; translational elongation
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Disease: Combined Oxidative Phosphorylation Deficiency 3
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Reference #:
P43897
(UniProtKB)
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Alt. Names/Synonyms: EF-Ts; EF-TsMt; EFT5; EFTS; EFTSMT; Elongation factor Ts, mitochondrial; mitochondrial elongation factor Ts; Ts translation elongation factor, mitochondrial; TSFM
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Gene Symbols: TSFM
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Molecular weight:
35,391 Da
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Basal Isoelectric point:
8.62
Predict pI for various phosphorylation states
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