hnRNP L Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding
Chromosomal Location of mouse Ortholog: 7|7 B1
Cellular Component:  chromatin; cytoplasm; nucleoplasm; nucleus; perinuclear region of cytoplasm; pronucleus; ribonucleoprotein complex; ribonucleoprotein granule; synapse
Molecular Function:  mRNA 3'-UTR binding; mRNA binding; mRNA CDS binding; nucleic acid binding; pre-mRNA intronic binding; protein binding; RNA binding; transcription cis-regulatory region binding
Biological Process:  mRNA processing; negative regulation of DNA-templated transcription; regulation of alternative mRNA splicing, via spliceosome; regulation of RNA splicing
Reference #:  Q8R081 (UniProtKB)
Alt. Names/Synonyms: C79783; D830027H13Rik; Heterogeneous nuclear ribonucleoprotein L; hnRNP L; Hnrnpl; Hnrpl
Gene Symbols: Hnrnpl
Molecular weight: 63,964 Da
Basal Isoelectric point: 8.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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hnRNP L

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein