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GMPS
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.5.2; Ligase; Nucleotide Metabolism - purine; Oncoprotein; Xenobiotic Metabolism - drug metabolism - other enzymes |
| Chromosomal Location of human Ortholog: 3q25.31 |
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Cellular Component:
cytosol
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Molecular Function:
ATP binding; GMP synthase (glutamine-hydrolyzing) activity; GMP synthase activity
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Biological Process:
glutamine metabolic process; GMP biosynthetic process; purine nucleobase biosynthetic process; purine ribonucleoside monophosphate biosynthetic process
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Disease: Leukemia, Acute Myeloid
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Reference #:
P49915
(UniProtKB)
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Alt. Names/Synonyms: GATD7; Glutamine amidotransferase; GMP synthase; GMP synthase [glutamine-hydrolyzing]; GMP synthetase; GMPS; GUAA; guanine monophosphate synthase; guanine monophosphate synthetase; guanine monphosphate synthetase; guanosine 5'-monophosphate synthase; MLL/GMPS fusion partner; MLL/GMPS fusion protein; testicular tissue protein Li 82
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Gene Symbols: GMPS
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Molecular weight:
76,715 Da
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Basal Isoelectric point:
6.42
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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