GMPS Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.5.2; Ligase; Nucleotide Metabolism - purine; Oncoprotein; Xenobiotic Metabolism - drug metabolism - other enzymes
Chromosomal Location of Human Ortholog: 3q25.31
Cellular Component:  cytosol
Molecular Function:  ATP binding; GMP synthase (glutamine-hydrolyzing) activity; pyrophosphatase activity
Biological Process:  glutamine metabolic process; GMP biosynthetic process; purine nucleobase biosynthetic process; purine ribonucleoside monophosphate biosynthetic process
Disease: Leukemia, Acute Myeloid
Reference #:  P49915 (UniProtKB)
Alt. Names/Synonyms: GATD7; Glutamine amidotransferase; GMP synthase; GMP synthase [glutamine-hydrolyzing]; GMP synthetase; GMPS; GUAA; guanine monophosphate synthase; guanine monophosphate synthetase; guanine monphosphate synthetase; guanosine 5'-monophosphate synthase; MLL/GMPS fusion partner; MLL/GMPS fusion protein; testicular tissue protein Li 82
Gene Symbols: GMPS
Molecular weight: 76,715 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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GMPS

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene