|
GMPS
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 6.3.5.2; Ligase; Nucleotide Metabolism - purine; Oncoprotein; Xenobiotic Metabolism - drug metabolism - other enzymes |
| Chromosomal Location of Human Ortholog: 3q25.31 |
|
Cellular Component:
cytosol
|
|
Molecular Function:
ATP binding; GMP synthase (glutamine-hydrolyzing) activity; pyrophosphatase activity
|
|
Biological Process:
glutamine metabolic process; GMP biosynthetic process; purine nucleobase biosynthetic process; purine ribonucleoside monophosphate biosynthetic process
|
|
Disease: Leukemia, Acute Myeloid
|
|
Reference #:
P49915
(UniProtKB)
|
|
Alt. Names/Synonyms: GATD7; Glutamine amidotransferase; GMP synthase; GMP synthase [glutamine-hydrolyzing]; GMP synthetase; GMPS; GUAA; guanine monophosphate synthase; guanine monophosphate synthetase; guanine monphosphate synthetase; guanosine 5'-monophosphate synthase; MLL/GMPS fusion partner; MLL/GMPS fusion protein; testicular tissue protein Li 82
|
|
Gene Symbols: GMPS
|
|
Molecular weight:
76,715 Da
|
|
Basal Isoelectric point:
6.42
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
