SLC27A2 Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precursors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes. Belongs to the ATP-dependent AMP-binding enzyme family. Expressed in liver, kidney, placenta and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Ligase; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 15q21.2
Cellular Component:  cytosol; endoplasmic reticulum lumen; endoplasmic reticulum membrane; integral component of endoplasmic reticulum membrane; integral component of peroxisomal membrane; peroxisomal membrane; plasma membrane; specific granule membrane
Molecular Function:  acyl-CoA ligase activity; ATP binding; decanoate-CoA ligase activity; enzyme binding; long-chain fatty acid-CoA ligase activity; phytanate-CoA ligase activity; pristanate-CoA ligase activity; signaling receptor binding; very long-chain fatty acid-CoA ligase activity
Biological Process:  bile acid biosynthetic process; fatty acid alpha-oxidation; fatty acid beta-oxidation; long-chain fatty acid import; long-chain fatty acid metabolic process; methyl-branched fatty acid metabolic process; neutrophil degranulation; protein targeting to peroxisome
Reference #:  O14975 (UniProtKB)
Alt. Names/Synonyms: ACSVL1; FACVL1; FATP-2; FATP2; Fatty acid transport protein 2; Fatty-acid-coenzyme A ligase, very long-chain 1; hFACVL1; HsT17226; Long-chain-fatty-acid--CoA ligase; S27A2; SLC27A2; solute carrier family 27 (fatty acid transporter), member 2; Solute carrier family 27 member 2; THCA-CoA ligase; Very long-chain acyl-CoA synthetase; very long-chain fatty-acid-coenzyme A ligase 1; Very long-chain-fatty-acid-CoA ligase; very-long-chain acyl-CoA synthetase; VLACS; VLCS
Gene Symbols: SLC27A2
Molecular weight: 70,312 Da
Basal Isoelectric point: 8.75  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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