SPAG1 May play a role in the cytoplasmic assembly of the ciliary dynein arms. May play a role in fertilization. Binds GTP and has GTPase activity. Present in most tissues, including lung, with the strongest expression in brain, colon, kidney, and testis. In sperm and testis, detected in particular in pachytene primary spermatocytes. Up-regulated in pancreatic tumor tissues and not in normal pancreatic tissue. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); Microtubule-binding
Chromosomal Location of Human Ortholog: 8q22.2
Cellular Component:  cytoplasm; cytosol
Molecular Function:  GTP binding; hydrolase activity
Biological Process:  axonemal dynein complex assembly; single fertilization
Disease: Ciliary Dyskinesia, Primary, 28
Reference #:  Q07617 (UniProtKB)
Alt. Names/Synonyms: CILD28; CT140; epididymis secretory protein Li 268; FLJ32920; HEL-S-268; HSD-3.8; Infertility-related sperm protein Spag-1; SP75; SPAG1; sperm associated antigen 1; Sperm-associated antigen 1; tetratricopeptide repeat-containing protein; TPIS; TPR-containing protein involved in spermatogenesis
Gene Symbols: SPAG1
Molecular weight: 103,638 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein