JAK1 Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. Note: This description may include information from UniProtKB.
Protein type: EC; JakA family; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component:  cytoplasm; cytoskeleton; cytosol; endosome; membrane; nucleus
Molecular Function:  ATP binding; CCR5 chemokine receptor binding; growth hormone receptor binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein phosphatase binding; protein tyrosine kinase activity; ubiquitin protein ligase binding
Biological Process:  cytokine-mediated signaling pathway; interferon-gamma-mediated signaling pathway; interleukin-12-mediated signaling pathway; interleukin-15-mediated signaling pathway; interleukin-2-mediated signaling pathway; interleukin-21-mediated signaling pathway; interleukin-27-mediated signaling pathway; interleukin-35-mediated signaling pathway; interleukin-6-mediated signaling pathway; interleukin-7-mediated signaling pathway; interleukin-9-mediated signaling pathway; intracellular signal transduction; MAPK cascade; peptidyl-tyrosine phosphorylation; positive regulation of sprouting angiogenesis; protein phosphorylation; regulation of interferon-gamma-mediated signaling pathway; response to antibiotic; type I interferon signaling pathway
Disease: Autoinflammation, Immune Dysregulation, And Eosinophilia
Reference #:  P23458 (UniProtKB)
Alt. Names/Synonyms: AIIDE; JAK-1; JAK1; JAK1A; JAK1B; Janus kinase 1; Janus kinase 1 (a protein tyrosine kinase); JTK3; Tyrosine-protein kinase JAK1
Gene Symbols: JAK1
Molecular weight: 133,277 Da
Basal Isoelectric point: 7.48  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  IL6 Signaling  |  Inhibition of Apoptosis  |  PI3K/Akt Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene