JAK1 Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. Note: This description may include information from UniProtKB.

Protein type: EC 2.7.10.2; Jak family; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group

Chromosomal Location of human Ortholog: 1p31.3

Cellular Component: cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; cytosol; endosome; extrinsic component of cytoplasmic side of plasma membrane; nucleus; plasma membrane

Molecular Function: ATP binding; CCR5 chemokine receptor binding; growth hormone receptor binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein phosphatase binding; protein tyrosine kinase activity; ubiquitin protein ligase binding

Biological Process: cell differentiation; cellular response to virus; cytokine-mediated signaling pathway; growth hormone receptor signaling pathway via JAK-STAT; interleukin-11-mediated signaling pathway; interleukin-15-mediated signaling pathway; interleukin-2-mediated signaling pathway; interleukin-4-mediated signaling pathway; interleukin-6-mediated signaling pathway; interleukin-9-mediated signaling pathway; intracellular signal transduction; positive regulation of homotypic cell-cell adhesion; positive regulation of protein localization to nucleus; positive regulation of sprouting angiogenesis; protein localization to cell-cell junction; protein phosphorylation; receptor signaling pathway via JAK-STAT; response to antibiotic; T-helper 17 cell lineage commitment; type I interferon-mediated signaling pathway; type II interferon-mediated signaling pathway; type III interferon-mediated signaling pathway; tyrosine phosphorylation of STAT protein

Disease: Autoinflammation, Immune Dysregulation, And Eosinophilia

Reference #: P23458 (UniProtKB)

Alt. Names/Synonyms: AIIDE; JAK-1; JAK1; JAK1A; JAK1B; Janus kinase 1; Janus kinase 1 (a protein tyrosine kinase); JTK3; Tyrosine-protein kinase JAK1

Gene Symbols: JAK1

Molecular weight: 133,277 Da

Basal Isoelectric point: 7.48 Predict pI for various phosphorylation states

CST Pathways: ErbB/HER Signaling | IL6 Signaling | Inhibition of Apoptosis | PI3K/Akt Signaling | Tyrosine Kinases & Substrates

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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JAK1

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