PKAR2A Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. Belongs to the cAMP-dependent kinase regulatory chain family. Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component:  cAMP-dependent protein kinase complex; centrosome; ciliary base; cytoplasm; cytosol; nucleotide-activated protein kinase complex; plasma membrane; plasma membrane raft; protein-containing complex
Molecular Function:  cAMP binding; cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; protein binding; protein domain specific binding; protein kinase A catalytic subunit binding; ubiquitin protein ligase binding
Biological Process:  activation of protein kinase A activity; blood coagulation; cellular response to glucagon stimulus; intracellular signal transduction; negative regulation of cAMP-dependent protein kinase activity; renal water homeostasis
Reference #:  P13861 (UniProtKB)
Alt. Names/Synonyms: cAMP-dependent protein kinase regulatory subunit RII alpha; cAMP-dependent protein kinase type II-alpha regulatory subunit; KAP2; MGC3606; PKAR2A; PKR2; PRKAR2; PRKAR2A; protein kinase A, RII-alpha subunit; protein kinase cAMP-dependent type II regulatory subunit alpha; protein kinase, cAMP-dependent, regulatory subunit type II alpha; protein kinase, cAMP-dependent, regulatory, type II, alpha
Gene Symbols: PRKAR2A
Molecular weight: 45,518 Da
Basal Isoelectric point: 4.96  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Parkinson's Disease
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Protein Structure Not Found.

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