CABYR May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium. Expressed in elongating spermatids and spermatozoa (at protein level). Isoform 1 is expressed in testis. Isoform 3 and isoform 5 are also expressed in brain, pancreas and numerous brain tumors. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Cancer Testis Antigen (CTA)
Chromosomal Location of human Ortholog: 18q11.2
Cellular Component:  cytoplasm; cytoskeleton; cytosol; motile cilium; nucleus; sperm end piece; sperm fibrous sheath; sperm principal piece
Molecular Function:  calcium ion binding; protein heterodimerization activity; SH3 domain binding
Biological Process:  epithelial cilium movement; sperm capacitation
Reference #:  O75952 (UniProtKB)
Alt. Names/Synonyms: CABYR; CABYRa; CABYRc; CABYRc/d; CABYRe; calcium binding tyrosine phosphorylation regulated; calcium binding tyrosine-(Y)-phosphorylation regulated; calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2); Calcium-binding protein 86; Calcium-binding tyrosine phosphorylation-regulated protein; calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2); Cancer/testis antigen 88; CBP86; CT88; fibrousheathin 2; Fibrousheathin II; Fibrousheathin-2; FSP-2; FSP2; MGC9117; testis tissue sperm-binding protein Li 84P; Testis-specific calcium-binding protein CBP86
Gene Symbols: CABYR
Molecular weight: 52,774 Da
Basal Isoelectric point: 4.51  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein