TREM1 Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of human Ortholog: 6p21.1
Cellular Component:  cell surface; extracellular region; plasma membrane
Molecular Function:  scaffold protein binding; signaling receptor activity; transmembrane signaling receptor activity
Biological Process:  adaptive immune response; chemokine production; cytokine production involved in immune response; humoral immune response; innate immune response; intracellular signal transduction; neutrophil chemotaxis; neutrophil-mediated killing of gram-negative bacterium
Reference #:  Q9NP99 (UniProtKB)
Alt. Names/Synonyms: CD354; TREM-1; TREM1; Triggering receptor expressed on monocytes 1; Triggering receptor expressed on myeloid cells 1; triggering-receptor TREM1
Gene Symbols: TREM1
Molecular weight: 26,387 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein