ERO1L Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. Belongs to the EROs family. Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum. Note: This description may include information from UniProtKB.
Protein type: EC 1.8.4.-; Oxidoreductase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 14q22.1
Cellular Component:  dendrite; endoplasmic reticulum; endoplasmic reticulum lumen; intracellular membrane-bounded organelle
Molecular Function:  oxidoreductase activity; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; protein binding
Biological Process:  4-hydroxyproline metabolic process; animal organ senescence; brown fat cell differentiation; cell redox homeostasis; cellular protein modification process; cellular response to hypoxia; cellular response to oxidative stress; chaperone cofactor-dependent protein refolding; endoplasmic reticulum unfolded protein response; extracellular matrix organization; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; oxidation-reduction process; protein folding; protein maturation by protein folding; release of sequestered calcium ion into cytosol; response to endoplasmic reticulum stress; response to temperature stimulus
Reference #:  Q96HE7 (UniProtKB)
Alt. Names/Synonyms: Endoplasmic oxidoreductin-1-like protein; ERO1-alpha; ERO1-L; ERO1-L-alpha; ERO1-like (S. cerevisiae); ERO1-like protein alpha; ERO1A; ERO1L; Oxidoreductin-1-L-alpha
Gene Symbols: ERO1A
Molecular weight: 54,393 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB