SEPT1 Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. Expressed at high levels in lymphoid and hematopoietic tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytoskeletal; Hydrolase
Chromosomal Location of mouse Ortholog: 7|7 F3
Cellular Component:  cytoplasm; cytoskeleton; meiotic spindle; microtubule cytoskeleton; midbody; septin complex; septin ring; synaptic vesicle
Molecular Function:  GTP binding; GTPase activity; identical protein binding; nucleotide binding
Biological Process:  cell cycle; cell division; cytoskeleton-dependent cytokinesis; meiotic metaphase plate congression; regulation of exocytosis; spindle assembly involved in female meiosis
Reference #:  P42209 (UniProtKB)
Alt. Names/Synonyms: Diff; Diff6; differentiation 6 (deoxyguanosine triphosphate triphosphohydrolase); Differentiation protein 6; OTTMUSP00000025010; Peanut-like protein 3; PNU; Pnutl3; Protein Diff6; Sep; Sept1; septin 1; Septin-1; Septin1
Gene Symbols: Sept1
Molecular weight: 42,020 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene