AHNAK a giant propeller-like protein that associates with calcium channel proteins of cardiomyocytes and other cells. Translocates from the cytosol to the plasma membrane during the formation of cell-cell contacts and the development of epithelial polarity. At the plasma membrane, it associates as a multimeric complex with actin and the annexin 2/S100A10 complex. The AHNAK/annexin 2/S100A10 complex regulates cortical actin cytoskeleton organization and the architecture of the cell membrane. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Adaptor/scaffold; Cytoskeletal
Chromosomal Location of Human Ortholog: 19|19 A
Cellular Component:  actin cytoskeleton; cell-cell contact zone; costamere; cytoplasm; cytosol; extracellular exosome; intercellular junction; membrane raft; nucleus; plasma membrane; sarcolemma; T-tubule; vesicle
Molecular Function:  S100 protein binding
Biological Process:  protein oligomerization; regulation of RNA splicing; regulation of voltage-gated calcium channel activity
Reference #:  E9Q616 (UniProtKB)
Alt. Names/Synonyms: 1110004P15Rik; 2310047C17Rik; AA589382; Ahnak; AHNAK nucleoprotein; AHNAK nucleoprotein (desmoyokin); Ahnak protein; AV091586; desmoyokin; DY6
Gene Symbols: Ahnak
Molecular weight: 604,253 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein