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SELENBP1
Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport. Belongs to the selenium-binding protein family. Widely expressed. Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of mouse Ortholog: 3 F2.1|3 40.74 cM |
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Cellular Component:
cytoplasm; fibrillar center; membrane; nucleolus; nucleus
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Molecular Function:
methanethiol oxidase activity; oxidoreductase activity; selenium binding
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Biological Process:
brown fat cell differentiation; oxidation-reduction process; protein transport
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Reference #:
P17563
(UniProtKB)
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Alt. Names/Synonyms: 56 kDa selenium-binding protein; Lp56; Lpsb; Methanethiol oxidase; MGC18519; MTO; OTTMUSP00000021242; SBP1; SBP56; Selenbp1; selenium binding protein 1; Selenium-binding protein 1; SP56
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Gene Symbols: Selenbp1
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Molecular weight:
52,514 Da
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Basal Isoelectric point:
5.87
Predict pI for various phosphorylation states
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