SELENBP1 Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport. Belongs to the selenium-binding protein family. Widely expressed. Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of mouse Ortholog: 3 F2.1|3 40.74 cM
Cellular Component:  cytoplasm; fibrillar center; membrane; nucleolus; nucleus
Molecular Function:  methanethiol oxidase activity; oxidoreductase activity; selenium binding
Biological Process:  brown fat cell differentiation; oxidation-reduction process; protein transport
Reference #:  P17563 (UniProtKB)
Alt. Names/Synonyms: 56 kDa selenium-binding protein; Lp56; Lpsb; Methanethiol oxidase; MGC18519; MTO; OTTMUSP00000021242; SBP1; SBP56; Selenbp1; selenium binding protein 1; Selenium-binding protein 1; SP56
Gene Symbols: Selenbp1
Molecular weight: 52,514 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene