DAZL RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts. Belongs to the RRM DAZ family. Testis specific. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Translation
Chromosomal Location of Human Ortholog: 17 C|17 25.86 cM
Cellular Component:  cytoplasm; nucleus; polysome; protein-containing complex
Molecular Function:  identical protein binding; mRNA 3'-UTR binding; mRNA binding; nucleic acid binding; protein binding; RNA binding; translation activator activity
Biological Process:  3'-UTR-mediated mRNA stabilization; cell differentiation; female meiosis II; germ cell development; multicellular organism development; oocyte maturation; oogenesis; positive regulation of meiotic nuclear division; positive regulation of translational initiation; regulation of translation; spermatogenesis
Reference #:  Q64368 (UniProtKB)
Alt. Names/Synonyms: Daz-l; Daz-like; DAZ-like autosomal; Dazh; Dazl; Dazl1; Dazla; Deleted in azoospermia-like; Deleted in azoospermia-like 1; MGC107400; Tpx; Tpx-; Tpx-2; Tpx2
Gene Symbols: Dazl
Molecular weight: 33,313 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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DAZL

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene