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CRLF1
Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development. Belongs to the type I cytokine receptor family. Type 3 subfamily. Highest levels of expression observed in spleen, thymus, lymph node, appendix, bone marrow, stomach, placenta, heart, thyroid and ovary. Strongly expressed also in fetal lung. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
| Chromosomal Location of mouse Ortholog: 8 B3.3|8 34.15 cM |
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Cellular Component:
CRLF-CLCF1 complex; external side of plasma membrane; extracellular region; receptor complex
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Molecular Function:
ciliary neurotrophic factor receptor binding; cytokine activity; cytokine binding; cytokine receptor activity
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Biological Process:
cytokine-mediated signaling pathway; negative regulation of motor neuron apoptotic process; negative regulation of neuron apoptotic process; positive regulation of cell population proliferation; positive regulation of tyrosine phosphorylation of STAT protein; ureteric bud development
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Reference #:
Q9JM58
(UniProtKB)
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Alt. Names/Synonyms: CLF-; CLF-1; CRL; Crlf1; CRLM-3; Crlm3; cytokine receptor like molecule 3; Cytokine receptor-like factor 1; Cytokine receptor-like molecule 3; Cytokine-like factor 1; Novel cytokine receptor 6; NR6; NR6.1
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Gene Symbols: Crlf1
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Molecular weight:
46,662 Da
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Basal Isoelectric point:
9.17
Predict pI for various phosphorylation states
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CST Pathways:
PI3K/Akt Signaling
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