CRLF1 Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development. Belongs to the type I cytokine receptor family. Type 3 subfamily. Highest levels of expression observed in spleen, thymus, lymph node, appendix, bone marrow, stomach, placenta, heart, thyroid and ovary. Strongly expressed also in fetal lung. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of mouse Ortholog: 8 B3.3|8 34.15 cM
Cellular Component:  CRLF-CLCF1 complex; external side of plasma membrane; extracellular region; receptor complex
Molecular Function:  ciliary neurotrophic factor receptor binding; cytokine activity; cytokine binding; cytokine receptor activity
Biological Process:  cytokine-mediated signaling pathway; negative regulation of motor neuron apoptotic process; negative regulation of neuron apoptotic process; positive regulation of cell population proliferation; positive regulation of tyrosine phosphorylation of STAT protein; ureteric bud development
Reference #:  Q9JM58 (UniProtKB)
Alt. Names/Synonyms: CLF-; CLF-1; CRL; Crlf1; CRLM-3; Crlm3; cytokine receptor like molecule 3; Cytokine receptor-like factor 1; Cytokine receptor-like molecule 3; Cytokine-like factor 1; Novel cytokine receptor 6; NR6; NR6.1
Gene Symbols: Crlf1
Molecular weight: 46,662 Da
Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene