HAAO Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. Belongs to the 3-HAO family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; EC; Oxidoreductase
Chromosomal Location of Human Ortholog: 17|17 E4
Cellular Component:  cytoplasm; cytosol; mitochondrial membrane
Molecular Function:  3-hydroxyanthranilate 3,4-dioxygenase activity; dioxygenase activity; ferrous iron binding; iron ion binding; metal ion binding; oxidoreductase activity; oxygen binding
Biological Process:  'de novo' NAD biosynthetic process from tryptophan; NAD biosynthetic process; neuron cellular homeostasis; oxidation-reduction process; pyridine nucleotide biosynthetic process; quinolinate biosynthetic process; quinolinate metabolic process; response to cadmium ion; response to zinc ion
Reference #:  Q78JT3 (UniProtKB)
Alt. Names/Synonyms: 0610007K21Rik; 0610012J07Rik; 3-HAO; 3-HAOxase; 3-hydroxyanthranilate 3,4-dioxygenase; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; 3HAO; Haao; HAD
Gene Symbols: Haao
Molecular weight: 32,804 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene