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HAAO
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. Belongs to the 3-HAO family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - tryptophan; EC 1.13.11.6; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 17|17 E4 |
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Cellular Component:
cytoplasm; cytosol; mitochondrial membrane
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Molecular Function:
3-hydroxyanthranilate 3,4-dioxygenase activity; dioxygenase activity; ferrous iron binding; iron ion binding; metal ion binding; oxidoreductase activity; oxygen binding
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Biological Process:
'de novo' NAD biosynthetic process from tryptophan; NAD biosynthetic process; neuron cellular homeostasis; pyridine nucleotide biosynthetic process; quinolinate biosynthetic process; quinolinate metabolic process; response to cadmium ion; response to zinc ion
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Reference #:
Q78JT3
(UniProtKB)
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Alt. Names/Synonyms: 0610007K21Rik; 0610012J07Rik; 3-H; 3-HAO; 3-HAOxase; 3-hydroxyanthranilate 3,4-dioxygenase; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; 3HAO; Haao; HAD
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Gene Symbols: Haao
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Molecular weight:
32,804 Da
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Basal Isoelectric point:
6.1
Predict pI for various phosphorylation states
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