RICTOR a regulatory binding partner of the kinase mTOR. Part of a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Rictor interacts with Cullin1-Rbx1 to form an E3 ubiquitin ligase complex, and promotes ubiquitination and degradation of SGK1. Shares homology with pianissimo from D. discoidieum, STE20p from S. pombe, and AVO3p from S. cerevisiae. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5p13.1
Cellular Component:  cytosol; TORC2 complex
Molecular Function:  protein binding; protein kinase binding; ribosome binding
Biological Process:  actin cytoskeleton reorganization; activation of protein kinase B activity; embryo development ending in birth or egg hatching; peptidyl-serine phosphorylation; positive regulation of actin filament polymerization; positive regulation of endothelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of TOR signaling; regulation of actin cytoskeleton organization; regulation of establishment of cell polarity; regulation of gene expression; regulation of GTPase activity; regulation of inflammatory response; regulation of peptidyl-serine phosphorylation; regulation of protein kinase B signaling; TOR signaling; viral process
Reference #:  Q6R327 (UniProtKB)
Alt. Names/Synonyms: AVO3 homolog; DKFZp686B11164; hAVO3; KIAA1999; mAVO3; MGC39830; PIA; pianissimo; Rapamycin-insensitive companion of mTOR; RICTOR; RICTR; RPTOR independent companion of MTOR, complex 2; TORC2-specific protein AVO3
Gene Symbols: RICTOR
Molecular weight: 192,218 Da
Basal Isoelectric point: 7.22  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB