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RICTOR
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. Belongs to the RICTOR family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system |
| Chromosomal Location of human Ortholog: 5p13.1 |
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Cellular Component:
cytosol; Golgi apparatus; TORC2 complex
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Molecular Function:
molecular adaptor activity; protein binding; protein kinase binding; protein serine/threonine kinase activator activity; ribosome binding
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Biological Process:
actin cytoskeleton organization; cellular response to nutrient levels; cytoskeleton organization; embryo development ending in birth or egg hatching; negative regulation of apoptotic process; peptidyl-serine phosphorylation; phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell growth; positive regulation of endothelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of TOR signaling; regulation of actin cytoskeleton organization; regulation of establishment of cell polarity; regulation of gene expression; regulation of GTPase activity; regulation of inflammatory response; regulation of peptidyl-serine phosphorylation; regulation of protein kinase B signaling; TORC2 signaling
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Reference #:
Q6R327
(UniProtKB)
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Alt. Names/Synonyms: AVO3; AVO3 homolog; DKFZp686B11164; hAVO3; KIAA1999; mAVO3; MGC39830; PIA; pianissimo; Rapamycin-insensitive companion of mTOR; RICTOR; RICTR; RPTOR independent companion of MTOR complex 2; RPTOR independent companion of MTOR, complex 2; TORC2-specific protein AVO3
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Gene Symbols: RICTOR
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Molecular weight:
192,218 Da
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Basal Isoelectric point:
7.22
Predict pI for various phosphorylation states
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CST Pathways:
Insulin Receptor Signaling
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mTOR Signaling
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PI3K/Akt Signaling
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Translation: eIF4E and p70S6K
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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